Secretagogues-peptides are widely used in recent years.
They are composed of specific fragments of amino acids and basically they boost endogenous growth hormone production and secretion from hypophysis (GHRH).
Peptides are cheaper in the market, because they are partially growth hormone, as promoters of it.
Each peptide has a specified unique sequence of amino acids and metabolic activity, thereby.
Sermorelin consists of 29 amino acids and is a well known peptide, used against growth hormone deficiency.
GH fragments are synthetic form of Ghrelin and stimulate appetite-hunger.
Somatomedin C, or insulin like growth factor (IGF-1) is a 70 amino acid peptide that antagonizes the secretion of somatotropin (GH) and has similar action on the metabolism of carbohydrates and fats. On the other hand, somatostatin (GHRIH) is the inhibitor peptide of somatotropin’s secretion, blocking essentially the secretion of GHRH.
Somatostatin (naturally released from pancreas) is administrated in cases of pituitary adenoma, in order to slow down excessive growth process and avoid gigantism.
Myostatin is a protein-peptide that blocks muscle growth, and so its inhibitor (MYOi) is also a powerful anabolic peptide.
Folistatin (FST) is administrated medically in atrophic cardiomyopathy and has regenerative properties for the myocardium.
As well as in idiopathic states accompanied with muscle cachexia in cancer, or muscular dystrophy, myositis (skeletal muscle inflammation), or in Duchenne muscular dystrophy, for example.
Researches of the New York University showed that the exogenous administration of somatotropin (HGH) had a negative effect on the values of myostatin (MYO), a peptide that blocks muscle growth.
In medicine, they have been tested experimentally in acquired immunodeficiency syndrome (AIDS – HIV infection), Duchenne muscular dystrophy, metabolic diseases (treatment of type 2 diabetes, Cushing’s syndrome) and against aging through cellular regeneration.